CSpace  > 2018期刊论文
Cell fate reprogramming through engineering of native transcription factors
Jauch, Ralf
2018-10-01
Source PublicationCURRENT OPINION IN GENETICS & DEVELOPMENT
Volume52Pages:109-116
AbstractCellular reprogramming using cocktails of transcription factors (TFs) affirms the epigenetic and developmental plasticity of mammalian cells. It demonstrates the ability of TFs to 'read' genetic information and to rewire regulatory networks in different cellular contexts. Silenced chromatin is not an impediment to the genome engagement by ectopically expressed TFs. Reprogramming TFs have been identified in diverse structural families that lack shared domains or sequence motifs. Interestingly, the reprogramming activity of non-redundant paralogous TFs can be switched with a few point mutations. These findings revealed that the sequence-function relationships influencing reprogramming are tied to subtle features directing genome wide binding. Therefore, endogenous reprogramming TFs are amenable to directed biomolecular engineering that opens up new avenues to optimize cell fate conversions.
Indexed BySCIE
Document Type期刊论文
Identifierhttp://ir.foo.ac.cn/handle/2SETSVCV/1475
Collection2018期刊论文
Recommended Citation
GB/T 7714
Jauch, Ralf. Cell fate reprogramming through engineering of native transcription factors[J]. CURRENT OPINION IN GENETICS & DEVELOPMENT,2018,52:109-116.
APA Jauch, Ralf.(2018).Cell fate reprogramming through engineering of native transcription factors.CURRENT OPINION IN GENETICS & DEVELOPMENT,52,109-116.
MLA Jauch, Ralf."Cell fate reprogramming through engineering of native transcription factors".CURRENT OPINION IN GENETICS & DEVELOPMENT 52(2018):109-116.
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