Exploring novel bioactive compounds from marine microbes
Lixin Zhang1,2,3; Rong An1,4; Jinping Wang4; Nuo Sun1,4; Si Zhang2; Jiangchun Hu5; Jun Kuai6
Source PublicationCurrent Opinion in Microbiology

The historical paradigm of the deep ocean as a biological ‘desert’ has shifted to one of a ‘rainforest’ owing to the isolation of many novel microbes and their associated bioactive compounds. Recently, there has been an explosion of information about novel bioactive compounds that have been isolated from marine microbes in an effort to further explore the relatively untapped marine microbes and their secondary metabolites for drug discovery. The microbes are recovered and purified from the ocean by both conventional and innovative isolation methods to obtain those previously thought to be ‘uncultivable’. To overcome the difficulties and limitations associated with cultivation techniques, several DNA-based molecular methods have been developed to bypass the culture-dependent bottleneck. Bioactive compounds isolated using the above strategies have not only shown importance in biotechnological and pharmaceutical applications but have also increased our understanding of the diversity of marine microbiota, ecosystem functions and the exploitable biology.

MOST Discipline Catalogue理学::生物学
Indexed BySCI
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Document Type期刊论文
Affiliation1.Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences
2.South China Sea Institute of Oceanology, Chinese Academy of Sciences
3.SynerZ Pharmaceuticals Inc
4.Department of Microbiology, Shandong University
5.Insititute of Applied Ecology, Chinese Academy of Sciences
6.Wyeth Research
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GB/T 7714
Lixin Zhang,Rong An,Jinping Wang,et al. Exploring novel bioactive compounds from marine microbes[J]. Current Opinion in Microbiology,2005,8(3):276-281.
APA Lixin Zhang.,Rong An.,Jinping Wang.,Nuo Sun.,Si Zhang.,...&Jun Kuai.(2005).Exploring novel bioactive compounds from marine microbes.Current Opinion in Microbiology,8(3),276-281.
MLA Lixin Zhang,et al."Exploring novel bioactive compounds from marine microbes".Current Opinion in Microbiology 8.3(2005):276-281.
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