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Integrated Approaches for Discovering Novel Drugs From Microbial Natural Products
Lixin Zhang1,2
Subtype
2005
PublisherHumana Press
Publication PlaceNew York City
Abstract

Historically, nature has provided the source for the majority of the drugs in use today. This owes in large part to their structural complexity and clinical specificity. However, only a small percentage of known microbial secondary metabolites have been tested as natural-product drugs. Natural-product programs need to become more efficient, starting with the collection of environmental samples, selection of strains, metabolic expression, genetic exploitation, sample preparation and chemical dereplication. A renaissance of natural products-based drug discovery is coming because of the trend of combining the power of diversified but low-redundancy natural products with systems biology and novel assays. This review will focus on integrated approaches for diversifying microbial naturalproduct strains and extract libraries, while decreasing genetic and chemical redundancy. Increasing the quality and quantity of different chemical compounds tested in diverse biological systems should increase the chances of finding new leads for therapeutic agents.

KeywordDiversity Microbial Natural Products Drug Discovery Redundancy Dereplication Synergy
Subject Area生物学 ; 基础医学
ISBN978-1-59259-976-9 ; 978-1-58829-383-1
DOI10.1007/978-1-59259-976-9_2
URL查看原文
Pages33-55
Language英语
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Document Type专著
Identifierhttp://ir.foo.ac.cn/handle/2SETSVCV/7
Collection中国科学院广州生物医药与健康研究院
Affiliation1.Guangzhou Institute of Biomedicine and Health Chinese Academy of Sciences
2.SynerZ Pharmaceuticals Inc
Recommended Citation
GB/T 7714
Lixin Zhang. Integrated Approaches for Discovering Novel Drugs From Microbial Natural Products[M]. New York City:Humana Press,2005.
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