CSpace
Targeting the trafficking of MT-MMP for anti-cancer therapy
Duanqing Pei; Baoming Qin; Xiao Chen; Shuhong Yang; Jun Fu; Yunkai Xu
2006-07
Conference Name第十五届国际药理学大会
Source Publication中国药理学会会议论文集
Issue27
Conference Date2-7 July 2006
Conference PlaceBeijing, China.
Author of Source中国药理学会
Publication PlaceBeijing
Publisher中国药理学会
Abstract

Following the successful completion of the human genome and the ongoing effort in human proteome, we believe the next wave of activity will be focused on the traffickome —the localization and transportation of all cellular proteins.To this end , we have embarked on a large scale screening for intracellular mediators for the trafficking of cell surface molecules such as MT1-MMP and EGFR.The strategy involves the cloning of more than 500 likely effectors in expression vectors and the construction of their corresponding siRNA vectors .These potential regulators have been screened for their ability to perturb the trafficking patterns ofMT1-MMP in MDCK and PC3 cells.The pos itive candidates are currently being evaluated by co-IP experiments to see if they interact directly with the previously identified adaptor proteins including dynamin, clathrin , components of the AP2 complex , and the PDZ containingMints.The long term goal is to construct a regulatory circuit that regulate the trafficking of MT-MMPs and identify potential targets upstream of MT-MMPs for drug development.

MOST Discipline Catalogue理学::生物学 ; 医学::药学(可授医学、理学学位)
Indexed BySCI
Language英语
Document Type会议论文
Identifierhttp://ir.foo.ac.cn/handle/2SETSVCV/887
Collection中国科学院广州生物医药与健康研究院
AffiliationGuangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Duanqing Pei,Baoming Qin,Xiao Chen,et al. Targeting the trafficking of MT-MMP for anti-cancer therapy[C]//中国药理学会. Beijing:中国药理学会,2006.
Files in This Item: Download All
File Name/Size DocType Version Access License
Targeting the traffi(30KB)会议论文 开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Duanqing Pei]'s Articles
[Baoming Qin]'s Articles
[Xiao Chen]'s Articles
Baidu academic
Similar articles in Baidu academic
[Duanqing Pei]'s Articles
[Baoming Qin]'s Articles
[Xiao Chen]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Duanqing Pei]'s Articles
[Baoming Qin]'s Articles
[Xiao Chen]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Targeting the trafficking of MT-MMP for anti-cancer therapy.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.