CSpace
Attenuation of cGVHD by C5a/C5aR blockade is associated with increased frequency of Treg
Yulian Wang; Peilong Lai; Xiaomei Chen; Chang He; Xin Huang; Suxia Geng; Chenwei Luo; Suijing Wu; Wei Ling; Liye Zhong; Zesheng Lu; Peng Li; Jianyu Weng; Xin Du
2017-06-15
Source PublicationScientific Reports
Volume7Issue:1Pages:3603
AbstractC5aR signaling plays an important role in the regulation of T cell activation and alloimmune responses in chronic graft-versus-host disease (cGVHD). However, direct evidence of this modulation and the efficacy of C5aR blockade in the treatment of cGVHD have not been demonstrated. We observed higher expression of C5aR on both monocytes and T cells of patients with cGVHD compared with healthy controls and non-GVHD patients after allogeneic hematopoietic stem cell transplantation. Our data also demonstrated a significant negative correlation between C5aR expression and regulatory T cells (Treg) frequency in cGVHD patients, indicating a potential role of C5aR in the generation and regulation of Treg. In addition, an in vitro experiment revealed C5aR deficiency promoted the development of Treg whereas C5a activation abolished the differentiation of Treg. Importantly, we found C5aR blockade by PMX53 attenuated the pathology of cGVHD and improved the survival of cGVHD mice. PMX53 had a direct regulatory effect on Treg commitment and increased TGF-β1 expression. Thus, C5aR signaling may induce and intensify cGVHD by down-regulating Treg induction. The modulation of C5aR activation by PMX53 may provide a potential therapy for cGVHD.
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.foo.ac.cn/handle/2SETSVCV/903
Collection中国科学院广州生物医药与健康研究院
Recommended Citation
GB/T 7714
Yulian Wang,Peilong Lai,Xiaomei Chen,et al. Attenuation of cGVHD by C5a/C5aR blockade is associated with increased frequency of Treg[J]. Scientific Reports,2017,7(1):3603.
APA Yulian Wang.,Peilong Lai.,Xiaomei Chen.,Chang He.,Xin Huang.,...&Xin Du.(2017).Attenuation of cGVHD by C5a/C5aR blockade is associated with increased frequency of Treg.Scientific Reports,7(1),3603.
MLA Yulian Wang,et al."Attenuation of cGVHD by C5a/C5aR blockade is associated with increased frequency of Treg".Scientific Reports 7.1(2017):3603.
Files in This Item: Download All
File Name/Size DocType Version Access License
2017001李鹏-Attenuatio(3150KB)期刊论文出版稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yulian Wang]'s Articles
[Peilong Lai]'s Articles
[Xiaomei Chen]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yulian Wang]'s Articles
[Peilong Lai]'s Articles
[Xiaomei Chen]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yulian Wang]'s Articles
[Peilong Lai]'s Articles
[Xiaomei Chen]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 2017001李鹏-Attenuation of cGVHD by C5aC5aR blockade is associated with increased frequency of Treg.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.