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Domain-functional analyses of PIWIL1 and PABPC1 indicate their synergistic roles in protein translation via 3 '-UTRs of meiotic mRNAs 期刊论文
BIOLOGY OF REPRODUCTION, 2018, 卷号: 99, 期号: 4, 页码: 773-788
Authors:  Wu, Yaoyao;  Xu, Kaibiao;  Qi, Huayu
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PIWIL1  PABPC1  protein translation  post-meiotic mRNAs  3 '-UTR  
Cell fate reprogramming through engineering of native transcription factors 期刊论文
CURRENT OPINION IN GENETICS & DEVELOPMENT, 2018, 卷号: 52, 页码: 109-116
Authors:  Jauch, Ralf
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Establishment of peripheral blood mononuclear cell-derived humanized lung cancer mouse models for studying efficacy of PD-L1/PD-1 targeted immunotherapy 期刊论文
MABS, 2018, 卷号: 10, 期号: 8, 页码: 1301-1311
Authors:  Lin, Shouheng;  Huang, Guohua;  Cheng, Lin;  Li, Zhen;  Xiao, Yiren;  Deng, Qiuhua;  Jiang, Yuchuan;  Li, Baiheng;  Lin, Simiao;  Wang, Suna;  Wu, Qiting;  Yao, Huihui;  Cao, Su;  Li, Yang;  Liu, Pentao;  Wei, Wei;  Pei, Duanqing;  Yao, Yao;  Wen, Zhesheng;  Zhang, Xuchao;  Wu, Yilong;  Zhang, Zhenfeng;  Cui, Shuzhong;  Sun, Xiaofang;  Qian, Xueming;  Li, Peng
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Non-small-cell-lung cancer  humanized mouse model  patient-derived-xenograft  anti-PD-L1  PD-1 monoclonal antibody  immunotherapy  
Lower genomic stability of induced pluripotent stem cells reflects increased non-homologous end joining 期刊论文
CANCER COMMUNICATIONS, 2019, 卷号: 38
Authors:  Zhang, Minjie;  Wang, Liu;  An, Ke;  Cai, Jun;  Li, Guochao;  Yang, Caiyun;  Liu, Huixian;  Du, Fengxia;  Han, Xiao;  Zhang, Zilong;  Zhao, Zitong;  Pei, Duanqing;  Long, Yuan;  Xie, Xin;  Zhou, Qi;  Sun, Yingli
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Genomic stability  DNA damage repair  iPSCs  ESCs  
Presenilin 1 deficiency suppresses autophagy in human neural stem cells through reducing gamma-secretase-independent ERK/CREB signaling 期刊论文
CELL DEATH & DISEASE, 2019, 卷号: 9
Authors:  Chong, Cheong-Meng;  Ke, Minjing;  Tan, Yuan;  Huang, Zhijian;  Zhang, Ke;  Ai, Nana;  Ge, Wei;  Qin, Dajiang;  Lu, Jia-Hong;  Su, Huanxing
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Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish 期刊论文
NATURE COMMUNICATIONS, 2019, 卷号: 9
Authors:  Zhao, Shaoyang;  Xia, Jianhong;  Wu, Xiuhua;  Zhang, Leilei;  Wang, Pengtao;  Wang, Haiyun;  Li, Heying;  Wang, Xiaoshan;  Chen, Yan;  Agnetti, Jean;  Li, Yinxiong;  Pei, Duanqing;  Shu, Xiaodong
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Directed Evolution of Reprogramming Factors by Cell Selection and Sequencing 期刊论文
STEM CELL REPORTS, 2019, 卷号: 11, 期号: 2, 页码: 593-606
Authors:  Veerapandian, Veeramohan;  Ackermann, Jan Ole;  Srivastava, Yogesh;  Malik, Vikas;  Weng, Mingxi;  Yang, Xiaoxiao;  Jauch, Ralf
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Identification of a Wells-Dawson polyoxometalate-based AP-2 gamma inhibitor with pro-apoptotic activity 期刊论文
BIOCHEMICAL JOURNAL, 2019, 卷号: 475, 页码: 1965-1977
Authors:  Hu, Jiamiao;  Tan, Si Kee;  Lim, Michelle Gek Liang;  Chang, Shie Hong;  Cui, Guimei;  Liu, Shanshan;  Narasimhan, Kamesh;  New, Siu Yee;  Wang, Xuecong;  Chen, Congling;  Chakravarty, Harapriya;  Kolatkar, Prasanna R.;  Tam, Kin Yip;  Lu, Qian;  Su, Xiaodi;  Jauch, Ralf;  Cheung, Edwin
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Diversity among POU transcription factors in chromatin recognition and cell fate reprogramming 期刊论文
CELLULAR AND MOLECULAR LIFE SCIENCES, 2018, 卷号: 75, 期号: 9, 页码: 1587-1612
Authors:  Malik, Vikas;  Zimmer, Dennis;  Jauch, Ralf
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POU  Transcriptional regulation  Cellular reprogramming  Pioneer TFs  
DNA-mediated dimerization on a compact sequence signature controls enhancer engagement and regulation by FOXA1 期刊论文
NUCLEIC ACIDS RESEARCH, 2019, 卷号: 46, 期号: 11, 页码: 5470-5486
Authors:  Wang, Xuecong;  Srivastava, Yogesh;  Jankowski, Aleksander;  Malik, Vikas;  Wei, Yuanjie;  del Rosario, Ricardo C. H.;  Cojocaru, Vlad;  Prabhakar, Shyam;  Jauch, Ralf
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The chromatin remodeling protein INO80 contributes to the removal of H2A.Z at the p53-binding site of the p21 gene in response to doxorubicin 期刊论文
FEBS JOURNAL, 2018, 卷号: 285, 期号: 17, 页码: 3270-3285
Authors:  Ding, Jian;  Yu, Chao;  Sui, Yi;  Wang, Lingyao;  Yang, Yang;  Wang, Fei;  Yao, Hongjie;  Xing, Feiyang;  Liu, Hongshen;  Li, Yana;  Shah, Junaid Ali;  Cai, Yong;  Jin, Jingji
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chromatin remodeling complex  histone variant H2A  Z  INO80  p21  transcription  
Design, synthesis, and biological evaluation of m-amidophenol derivatives as a new class of antitubercular agents 期刊论文
MEDCHEMCOMM, 2019, 卷号: 9, 期号: 8, 页码: 1293-1304
Authors:  Zhang, Niu-niu;  Liu, Zhi-yong;  Liang, Jie;  Tang, Yun-xiang;  Qian, Lu;  Gao, Ya-min;  Zhang, Tian-yu;  Yan, Ming
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Design, synthesis and biological evaluation of novel pyrrole derivatives as potential ClpP1P2 inhibitor against Mycobacterium tuberculosis 期刊论文
BIOORGANIC CHEMISTRY, 2018, 卷号: 80, 页码: 422-432
Authors:  Liu, Pingxian;  Yang, Yang;  Ju, Yuan;  Tang, Yunxiang;  Sang, Zitai;  Chen, Lijuan;  Yang, Tao;  An, Qi;  Zhang, Tianyu;  Luo, Youfu
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Anti-tubercular  ClpP1P2 peptidase  Pyrrole derivatives  
Engineering CRISPR/Cpf1 with tRNA promotes genome editing capability in mammalian systems 期刊论文
CELLULAR AND MOLECULAR LIFE SCIENCES, 2018, 卷号: 75, 期号: 19, 页码: 3593-3607
Authors:  Wu, Han;  Liu, Qishuai;  Shi, Hui;  Xie, Jingke;  Zhang, Quanjun;  Ouyang, Zhen;  Li, Nan;  Yang, Yi;  Liu, Zhaoming;  Zhao, Yu;  Lai, Chengdan;  Ruan, Degong;  Peng, Jiangyun;  Ge, Weikai;  Chen, Fangbing;  Fan, Nana;  Jin, Qin;  Liang, Yanhui;  Lan, Ting;  Yang, Xiaoyu;  Wang, Xiaoshan;  Lei, Zhiyong;  Doevendans, Pieter A.;  Sluijter, Joost P. G.;  Wang, Kepin;  Li, Xiaoping;  Lai, Liangxue
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CRISPR/Cpf1  gRNA(tRNA) system  Genome editing  Rabbit  Pig  
Highly efficient RNA-guided base editing in rabbit 期刊论文
NATURE COMMUNICATIONS, 2019, 卷号: 9
Authors:  Liu, Zhiquan;  Chen, Mao;  Chen, Siyu;  Deng, Jichao;  Song, Yuning;  Lai, Liangxue;  Li, Zhanjun
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Copper-Catalyzed Bromodifluoroacetylation of Alkenes with Ethyl Bromodifluoroacetate 期刊论文
JOURNAL OF ORGANIC CHEMISTRY, 2019, 卷号: 83, 期号: 17, 页码: 10445-10452
Authors:  Li, Dengke;  Mao, Tingting;  Huang, Jinbo;  Zhu, Qiang
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The homeobox transcription factor MSX2 partially mediates the effects of bone morphogenetic protein 4 (BMP4) on somatic cell reprogramming 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 卷号: 293, 期号: 38, 页码: 14905-14915
Authors:  Lin, Lilong;  Liang, Lining;  Yang, Xiao;  Sun, Hao;  Li, Yuan;  Pei, Duanqing;  Zheng, Hui
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reprogramming  bone morphogenetic protein (BMP)  cadherin-1 (CDH1)  epithelial cadherin (E-cadherin)  GATA transcription factor  Kruppel-like factor 4 (KLF4)  homeobox transcription factor  MET  Msx2  Sall4  stem cell  
Incorporation of NS1 and prM/M are important to confer effective protection of adenovirus-vectored Zika virus vaccine carrying E protein 期刊论文
NPJ VACCINES, 2019, 卷号: 3
Authors:  Liu, Xinglong;  Qu, Linbing;  Ye, Xianmiao;  Yi, Changhua;  Zheng, Xuehua;  Hao, Mingli;  Su, Wan;  Yao, Zhipeng;  Chen, Peihai;  Zhang, Shengnan;  Feng, Yupeng;  Wang, Qian;  Yan, Qihong;  Li, Pingchao;  Li, Heying;  Li, Feng;  Pan, Weiqi;  Niu, Xuefeng;  Xu, Ruian;  Feng, Liqiang;  Chen, Ling
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Seven Novel and Three Known Mutations in FOXL2 in 10 Chinese Families with Blepharophimosis Syndrome 期刊论文
CURRENT MOLECULAR MEDICINE, 2018, 卷号: 18, 期号: 3, 页码: 152-159
Authors:  Lin, B.;  Zeng, B.;  Zhao, J.;  Xu, T.;  Wang, Y.;  Hu, B.;  Li, F.;  Zhao, Q.;  Liu, R.;  Liu, J.;  Chen, J. M.;  Huang, D.
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Blepharophimosis syndrome  BPES  FOXL2  ophthalmology  mutation  structural modeling  
Activation of hypothalamic RIP-Cre neurons promotes beiging of WAT via sympathetic nervous system 期刊论文
EMBO REPORTS, 2018, 卷号: 19, 期号: 4
Authors:  Wang, Baile;  Li, Ang;  Li, Xiaomu;  Ho, Philip Wl;  Wu, Donghai;  Wang, Xiaoqi;  Liu, Zhuohao;  Wu, Kelvin K. L.;  Yau, Sonata S. Y.;  Xu, Aimin;  Cheng, Kenneth K. Y.
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AMPK  beiging  hypothalamus  obesity  sympathetic nervous system